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Biomolecules Activity - Build a Protein Model to learn Protein Folding!

Science of Curiosity
Grade Levels
9th - 12th, Homeschool
Resource Type
Formats Included
  • PDF
9 pages
Science of Curiosity
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  1. This BUNDLE includes all EIGHT Biomolecules products from Science of Curiosity! Everything you need to teach your students about Carbohydrates, Lipids, Proteins and Nucleic Acids! A set of Doodle Notes - a full page for each Biomolecule (Carbohydrates, Lipids, Proteins, and Nucleic Acids)Protein Fol
    Price $15.00Original Price $18.00Save $3.00


A fun Protein activity to to teach protein folding for your Biomolecules unit. Teach protein folding in an interactive and creative way. Students will answer the question ‘Why and how do proteins fold up into 3D shapes?’ by actually making their own protein model!

This resource includes:

  • Student handout with content and reflection questions (one page, front and back)
  • Answer key
  • The PolyPeptide chain page, used for making the 3D protein
  • A detailed four page, five step teaching guide

In the past, my students struggled to understand why proteins folded up, the 20 different amino acids, peptide bonds….it all became a messy blur to them. They need a way to actually see protein folding in real life. Since starting to use this activity, my kids really understand what is going on. They can see the link between the R-Groups (side chains), the order of the amino acids, and the shape of the protein.

If you choose to do the entire activity, it will take about 60 minutes. The teaching guide includes adjustments to reduce the amount of time needed.

Includes ideas for using this model to teach the four stages of protein folding for more advanced or AP classes!

Easy set up! Students only need two print outs from this resource, and tape! Colored pencils or markers are optional.

Use this activity to connect to new content again and again throughout the year.

Making a protein lays a great foundation for discussing

  • Nucleic Acids: How does your cell know what order the amino acids should be in?Mutations: What if this one amino acid were different? Or missing?
  • Denatured enzymes: The 3D proteins you make can also be used to demonstrate when proteins are denatured by heat, acid or base.


Looking for more teaching resources for Biomolecules?

Doodle Notes!

More Biology resources from Science of Curiosity!

** Stay Curious! **

Total Pages
9 pages
Answer Key
Teaching Duration
1 hour
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to see state-specific standards (only available in the US).
Construct and revise an explanation based on evidence for how carbon, hydrogen, and oxygen from sugar molecules may combine with other elements to form amino acids and/or other large carbon-based molecules. Emphasis is on using evidence from models and simulations to support explanations. Assessment does not include the details of the specific chemical reactions or identification of macromolecules.


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